There have been an increasing number of peer-reviewed publications investigating refined mouse handling. At least 19 peer-reviewed publications support the use of refined mouse handling. They find that refined mouse handling improves mouse welfare and scientific quality.
You can find a list of the publications cited here and a brief description of their findings below. For a more extensive summary of each paper’s methods and findings, see NC3Rs mouse handling research summary.
NOTE: the results from this study and the projected cost savings as a result of increased breeding productivity were significant enough to persuade a change in the standard of care across the institution (University of Florida)