Microphysiological Systems Initiative

We collaborate to increase industry adoption & regulatory acceptance of microphysiological systems.

While animal models have established value to biomedical research, they also have limitations. Microphysiological systems (MPS) hold promise to overcome some of these limitations with the promise of serving as a reduction or replacement.

MPS are an emerging technology that holds the potential to increase translation, efficiency, efficacy, and safety. They could serve as a replacement for some parts of animal research and become an integral part of drug development. What are MPS? They include tissue models such as spheroids, organoids, and organs-on-chips.

The NA3RsC MPS Initiative is comprised of 82 representatives from 39 institutions, 28 that are providers of commercially-available MPS that are already translated into industry use as well as several end-users. Its principal goal is to increase the adoption of MPS technologies through stakeholder engagement. We also hold representation in the planning of the MPS World Summit.

Our initiative is focused on four main areas shown below.

MPS Conferences & Events

Commercial Technology Hub

Interfacing with End-Users

Regulatory Acceptance

New to MPS? Watch our Introduction to Microphysiological Systems below.


To learn about the current status of MPS in North America view our below video created for the MPS World Summit in June 2022.


To learn more about our initiative and our perspectives on MPS regulatory acceptance, you can view the below presentations.

3D Tissue Models Summit – May 2022

Addressing the need to outline regulatory guidance & clarity for 3D Tissue Models

MPS World Summit – June 2021

Play Video about A roadmap to overcoming obstacles to MPS regulatory acceptance

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Podcast: 3-Minute 3Rs