Organ-on-a-chip model of vascularized human bone marrow niches

This publication presents a 3D in vitro model of human bone marrow that contains both the perivascular and endosteal niches, complete with dynamic, perfusable vascular networks to replicate in vivo bone marrow function, including maintenance and differentiation.

NETRI

NETRI is an industrial start-up developing innovative technologies for the pharmaceutical industry. Its patented organs-on-chip technologies allow the creation of standardized and predictive human in vitro models.

React4Life

React4Life provides MIVO® organ-on-chip technology for advanced in vitro testing. Our platform can closely replicate human physiology by hosting 3D human cells or clinically relevant sized tissues under precisely controlled fluid dynamic conditions. Our multi-organ configuration enables simultaneous investigations into drug efficacy and cytotoxic effects, providing a more comprehensive and relevant context.

AlveoliX

AlveoliX is a Swiss-based organ-on-chip company. Our product is comprised of different hardware components and the easy-to-handle organ-on-chip consumable AX12. On the AX12 healthy and diseased biomodels can be created to study drug safety and efficacy and to answer fundamental research questions.

KIYATEC

KIYATEC’s clinically validated, predictive 3D ex vivo assays characterize response to I/O, targeted, and chemo therapies. Data from our proprietary platforms span most solid tumors including ovarian, GBM, breast, & rare. Our services cover all phases of preclinical development thru clinical trials.

Aracari Bio

Aracari’s vascularized micro-organ and tumor models incorporate perfused human vasculature for the physiologic delivery of nutrients, drugs and immune cells to multiple tissue and tumor types. These powerful next-generation tools are advancing discovery in immuno-oncology and drug development.

SynVivo, Inc.

Organ-on-Chip models from SynVivo recreate complex microvasculature including scale, morphology, hemodynamic shear stress, and cellular interactions in a perfused microfluidic chip environment. Validated models include Air Liquid Interface for Lung, Blood-Brain Barrier, Tumor, DIVI, Inflammation.

Hesperos Inc.

Hesperos is accelerating drug discovery by providing safety and efficacy testing services using its Human-on-a-Chip, microphysiological system. This breakthrough technology enables unprecedented preclinical insight bringing better therapies to patients faster without the need for animal testing.

TissUse

TissUse is a Berlin, Germany-based, biotechnology company who has developed a unique HUMIMIC Multi-Organ-Chip platform for advanced toxicity testing and cutting-edge disease modelling.